Discussion on the Technical Ways to Solve the Existing Problems of Rolling Mode Soft Capsule Machine

Abstract: Introduce the basic concept of soft capsule dosage form, the existing problems of capsule machine, and propose the technical way to solve the existing problems. Key words: fully independent drive automatic proofreading time

1 Introduction <br> soft capsule dosage form is a capsule after tablets, injections, oral liquid developed a new dosage form, do not have hard capsules and soft capsules. The soft capsule refers to a sealed capsule capable of injecting an oily functional substance, a functional substance solution or a functional substance powder into a gelatin film to form a size and a shape.

2 Several key factors in the formation of soft capsules 2.1 The formation process of soft capsules Gelatin liquid is insulated by thermal insulation rubber barrel and flows into the gelatin box by air pressure or gravity. It is still in the flowing liquid state under the heat preservation of gelatin box. The bottom gap (adjustable) flows out onto the rubber wheel. The flowing gelatin forms a gelatin film of uniform thickness under the action of the uniform rotation of the rubber wheel. Through the cooling action of the rubber wheel and the drying action of the rubber fan, the temperature of the gelatin film drops to about 25 ° C, and part of the moisture is removed, so that the gelatin film has Stronger dynamic performance. After the gelatin film is rotated on the rubber wheel for about one week, it is separated from the rubber wheel and enters the oil rolling system through the conveying mechanism (rubber rolling system) to lubricate the rubber film on both sides to reduce the friction and viscosity between the gelatin film and other parts. Sexuality, relying on its own elasticity to maintain a uniform thickness, and to ensure that the soft capsule does not stick to the mold and the spray body during the formation process. After zui, the gelatin film enters between the spray and the left and right molds (see Figure 1). The gelatin film restores good adhesion by heating with a heating rod mounted on the spray body. During the process of extrusion, bonding and shearing of two gelatin films by the mold cavity, the feed pump can form a soft capsule through the reciprocating motion of the plunger through the spray body to inject between the two gelatin films. It is.
2.2 Factors Affecting Soft Capsule Formation The quality of soft capsule formation is affected by many factors, such as the various parameters of gelatin's own characteristics, the ratio of various materials when melted, etc., and will not be discussed here. The factors related to the soft capsule machine mainly include the holding temperature of the gelatin film, the cooling temperature of the rubber wheel, the heating temperature of the spray body, the alignment of the left and right molds, and the injection time of the plunger. The existing soft capsule machine satisfactorily solves the temperature control and monitoring problems in the above capsule formation process through the PLC control system and PID adjustment. However, the injection time of the left and right molds on the line and the plunger is adjusted by the experience of the operator, and there is a strong uncertainty factor that directly affects the formation and loading of the soft capsule.
The injection time of the plunger is a dynamic process. As the mold rotates, the spray holes on the spray body move relative to the mold cavity. The injection time should not be too early, because when the gelatin film is squeezed and sheared under the mold cavity, it takes a certain time to bond, thus forming a complete bucket type plastic box. Only when the gelatin film begins to bond and then the drug is injected, can the liquid solution be completely encapsulated in the soft capsule without overflowing from the seam of the capsule, resulting in inaccurate loading and affecting the formation of other capsules. The injection time should not be too late. Too late will affect the joints above the gelatin film. The joints will not be completely bonded or the bonding area will be too small, which will cause the leaking pills to be easily crushed during the drying process of the late rolling cage, which will affect the yield. And a large area affects the hygiene of other soft capsules. Therefore, the reasonable time for injection should be in the middle of the soft capsule formation process.
Take the 250 mold of Beijing Changzheng Tianmin High-Tech Co., Ltd. as an example. When the spindle speed is 1 rpm, the whole formation process of the soft capsule is about 1.6 seconds, and the reasonable injection time is about 0.5-0.8 seconds. It is difficult to control precisely by the experience of the operator. If the mold cavity becomes smaller or the rotational speed increases, the actual reasonable injection time zone is shorter, which is basically uncontrollable, and can only be achieved by trial and error operations. Therefore, relying on the operator to achieve the accuracy of the injection time is likely to cause a lot of manpower and material resources to be wasted during the preliminary test and post-processing, resulting in unnecessary economic losses.

3 fully independent drive scheme <br> order to solve the problem of the accuracy of the plunger injection time, the Beijing-day long march people high-tech companies put a lot of technology demonstration program and test, zui finalized a fully independent drive way to solve the problem .
Conventional capsule machines are generally driven by a single motor, and mechanical movements between the components are used to achieve coordinated action. The mechanical transmission has the outstanding advantages of synchronous effect and can meet the requirements of use. However, the method has the disadvantages of strong dependence on people in the adjustment mentioned above, and also requires high processing precision (especially shape tolerance), resulting in high production cost and requirements for inspection equipment; Moreover, after the rotation speed is increased, since the gelatin film is elastic, there is a phenomenon that the laminating film or the gelatin film sag. Our company launched the RGY10-15 soft capsule machine in 2005, trying to solve the above problems with a fully independent drive solution. As the * step of the scheme, for some related components, such as the left and right rubber wheel and the pull net shaft, separate driving devices are adopted, and the technical solution of the synchronization problem is solved by the control system, and the mechanical speed of the main engine is changed. The effect of the drive on the gelatin film. The adjustment between the feed pump and the head is made by means of a pneumatic clutch. Although the operation is more improved than the conventional one, it still requires the experience of the operator and still causes waste of manpower and material resources. The new generation of soft capsule machine developed by Beijing Changzheng Tianmin High-Tech Co., Ltd. is going to adopt a fully independent drive solution, which is expected to solve this problem that has not been solved.
The fully independent drive scheme, that is, the feed pump of the RGY10-15 soft capsule machine that also shares a drive unit with the main unit is driven separately from the main unit. Using the AC asynchronous motor servo control principle, the rotary code conversion is performed at the position where the plunger starts to be injected, and becomes a corresponding point on the circumference so as to correspond to the plunger injection time. After the main motor is started, the mold is driven to rotate. When the detecting device detects the zero mark on the mold, it sends a zero signal to the PLC. After receiving the signal, the PLC sends a signal to the servo to control the asynchronous AC motor to start working, and automatically finds the zero point that follows the main motor. When the zero point is confirmed, the servo controller locks the speed ratio, keeps the main motor and the feed pump motor synchronized, and the automatic proofing injection time process is completed.

4 Conclusion <br> servo motor has an output torque control function, the control range of 0 to 300% of the motor torque control precision ± 5%, choose a smaller power motors, to meet the requirements of the feed pump drive force; the The position control accuracy of the motor is ±1P (zui can be divided into 10000P), and it can be verified once every working cycle to ensure accurate injection time; speed control accuracy ±0.02%, speed range 1:25000, guarantee complete With the follow-up function of the main motor controlled by the inverter; low speed and large torque output, zero speed torque maintenance, to ensure the reliability and accuracy of working at different speeds. It has been proved by experiments that the fully independent driving method has the outstanding advantages of high control precision, high reliability and low energy loss, which can effectively solve the problems existing in the existing capsule machine.

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