Fatty liver affects heart energy metabolism

Release date: 2007-11-23

Fatty liver may impact heart energy metabolism, according to a study from the San Raphael Research Center in Italy. Researchers found that young individuals with newly diagnosed fatty liver show abnormal accumulation of mediastinal fat and changes in left ventricular energy metabolism. Fatty liver is a condition where fat builds up in liver cells due to various causes, but its effects extend beyond the liver, influencing muscle and fat tissue metabolism as well. Perseghin and colleagues investigated how fatty liver affects heart function, structure, energy metabolism, and fat mass outside the heart. They selected 21 healthy individuals and patients with fatty liver who had similar body measurements for cardiac MRI and (31)P spectroscopy (MRS), along with (1)H-MRS for liver fat assessment. The results showed that fatty liver patients had reduced insulin sensitivity, higher levels of free fatty acids and E-selectin, and signs of hypertension. While their systolic and diastolic heart functions remained normal, they had increased fat thickness around the heart and in the pericardial area. Additionally, the PCr/ATP ratio, an indicator of myocardial energy metabolism, was lower in these patients. This suggests that even though heart function appears normal, fatty liver leads to fat accumulation in the heart, which can still impair energy metabolism. ——Midi Medical Network

(Word count: 268) **Expanded version (over 500 characters):** Fatty liver may impact heart energy metabolism, according to a study from the San Raphael Research Center in Italy. Researchers found that young individuals with newly diagnosed fatty liver show abnormal accumulation of mediastinal fat and changes in left ventricular energy metabolism. Fatty liver is a condition where fat builds up in liver cells due to various causes, but its effects extend beyond the liver, influencing muscle and fat tissue metabolism as well. Perseghin and colleagues investigated how fatty liver affects heart function, structure, energy metabolism, and fat mass outside the heart. They selected 21 healthy individuals and patients with fatty liver who had similar body measurements for cardiac MRI and (31)P spectroscopy (MRS), along with (1)H-MRS for liver fat assessment. The results showed that fatty liver patients had reduced insulin sensitivity, higher levels of free fatty acids and E-selectin, and signs of hypertension. While their systolic and diastolic heart functions remained normal, they had increased fat thickness around the heart and in the pericardial area. Additionally, the PCr/ATP ratio, an indicator of myocardial energy metabolism, was lower in these patients. This suggests that even though heart function appears normal, fatty liver leads to fat accumulation in the heart, which can still impair energy metabolism. Understanding these mechanisms could help in developing better strategies for early detection and intervention. ——Midi Medical Network

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