Fatty liver affects heart energy metabolism
Release date: 2007-11-23
New research from the San Raphael Research Center in Italy reveals that young individuals diagnosed with fatty liver disease show abnormal accumulation of fat in the mediastinum and changes in left ventricular energy metabolism. Fatty liver, also known as hepatic steatosis, occurs when excess fat builds up in liver cells due to various factors. However, this condition doesn't just affect the liver—it also disrupts the metabolism of skeletal muscles and adipose tissue. Perseghin and colleagues investigated how fatty liver impacts heart function, structure, energy metabolism, and fat distribution outside the heart. They selected 21 healthy individuals and 21 patients with fatty liver who had similar body measurements for a detailed analysis using cardiac magnetic resonance imaging (MRI) and (31)P spectroscopy (MRS), along with (1)H-MRS for liver fat assessment. The study found that fatty liver patients exhibited reduced insulin sensitivity, higher levels of free fatty acids and E-selectin, and were more likely to have hypertension. Although their systolic and diastolic heart functions remained normal, they showed increased fat deposits around the heart and in the pericardial area. Moreover, the PCr/ATP ratio, an important indicator of myocardial energy metabolism, was significantly lower in these patients. This suggests that even though the heart’s pumping function appears normal, fatty liver can still negatively impact the energy production within heart muscle cells. These findings highlight the broader implications of fatty liver disease on cardiovascular health, beyond what is typically observed in routine exams. ——Midi Medical Network
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